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Extremely low activity of methionine synthase in vitamin B-12-deficient rats may be related to effects on coenzyme stabilization rather than to changes in coenzyme induction

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On the one hand, PGC-1 stimulates mitochondrial biogenesis by enhancing NRF1 transcriptional activity and TFAM gene expression

Unlike vitamin C, vitamin E, and polyphenols that indiscriminately neutralize all reactive species (including beneficial signaling molecules), molecular hydrogen targets only the most damaging oxidants like hydroxyl radicals while preserving normal redox signaling